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Issue 2, 2010
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Cloning and heterologous expression of the spectinabilin biosynthetic gene cluster from Streptomyces spectabilis

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Abstract

Spectinabilin is a rare nitrophenyl-substituted polyketidemetabolite. Here we report the cloning and heterologous expression of the spectinabilin gene cluster from Streptomyces spectabilis. Unexpectedly, this gene cluster is evolutionarily closer to the aureothin gene cluster than to the spectinabilin gene cluster from Streptomyces orinoci. Moreover, the two nearly identical spectinabilin gene clusters use a distinctly different regulation mechanism.

Graphical abstract: Cloning and heterologous expression of the spectinabilin biosynthetic gene cluster from Streptomyces spectabilis

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Publication details

The article was received on 05 Nov 2009, accepted on 20 Nov 2009 and first published on 22 Dec 2009


Article type: Communication
DOI: 10.1039/B923177C
Mol. BioSyst., 2010,6, 336-338

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    Cloning and heterologous expression of the spectinabilin biosynthetic gene cluster from Streptomyces spectabilis

    Y. S. Choi, T. W. Johannes, M. Simurdiak, Z. Shao, H. Lu and H. Zhao, Mol. BioSyst., 2010, 6, 336
    DOI: 10.1039/B923177C

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