In vivo        siRNA delivery with dendritic poly(L-lysine) for the treatment of hypercholesterolemia

Kazuto Watanabe; Mariko Harada-Shiba; Akira Suzuki; Risa Gokuden; Ryohsuke Kurihara; Yusuke Sugao; Takeshi Mori; Yoshiki Katayama; Takuro Niidome

doi:10.1039/B900880B

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In vivosiRNA delivery with dendritic poly(l-lysine) for the treatment of hypercholesterolemia†‡

Kazuto Watanabe,^a Mariko Harada-Shiba,^b Akira Suzuki,^b Risa Gokuden,^a Ryohsuke Kurihara,^a Yusuke Sugao,^a Takeshi Mori,^ac Yoshiki Katayama^ac and Takuro Niidome*^acd

Author affiliations

* Corresponding authors

^a Department of Applied Chemistry, Faculty of Engineering, Kyushu University, Fukuoka 819-0395, Japan
E-mail: niidome.takuro.655@m.kyushu-u.ac.jp
Fax: +81-92-802-2851
Tel: +81-92-802-2851

^b Department of Bioscience, National Cardiovascular Center Research Institute, Suita, Osaka 565-8565, Japan

^c Center for Future Chemistry, Kyushu University, Fukuoka 819-0395, Japan

^d PRESTO, Japan Science and Technology Corporation, Kawaguchi 332-0012, Japan

Abstract

Intravenous delivery of apolipoprotein B-specific siRNA with a sixth-generation of dendritic poly(L-lysine) (KG6) resulted in siRNA-mediated knockdown of ApoB in healthy C57BL/6 mice without hepatotoxicity, and with a significant reduction of serum low-density lipoprotein cholesterol in apolipoprotein E-deficient mice.

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Article information

DOI: https://doi.org/10.1039/B900880B
Article type: Communication
Submitted: 30 Jan 2009
Accepted: 12 Aug 2009
First published: 21 Aug 2009

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Mol. BioSyst., 2009,5, 1306-1310

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In vivo siRNA delivery with dendritic poly(L-lysine) for the treatment of hypercholesterolemia

K. Watanabe, M. Harada-Shiba, A. Suzuki, R. Gokuden, R. Kurihara, Y. Sugao, T. Mori, Y. Katayama and T. Niidome, Mol. BioSyst., 2009, 5, 1306 DOI: 10.1039/B900880B

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Molecular BioSystems