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Issue 12, 2008

Structural dissection of the extracellular moieties of the type III secretion apparatus

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Abstract

Many Gram-negative bacterial pathogens use type III secretion systems (TTSSs) for subverting the normal cellular functions of their target eukaryotic cells. The type III secretion apparatus (TTSA) functions like a syringe to inject proteins through an external needle and into a target cell’s membrane and cytosol. The TTSA basal body spans the bacterial inner and outer membranes, and the external needle is topped with a tip complex that controls the secretion and delivery of translocator and effectorproteins. Recently solved structures of TTSAproteins have greatly advanced our understanding of shared themes in apparatus assembly and function. In this highlight, the structure–function of TTSA needle and tip complex proteins are described and common themes discussed.

Graphical abstract: Structural dissection of the extracellular moieties of the type III secretion apparatus

Article information


First published
18 Sep 2008

Mol. BioSyst., 2008,4, 1176-1180
Article type
Highlight

Structural dissection of the extracellular moieties of the type III secretion apparatus

Y. Wang, L. Zhang, W. L. Picking, W. D. Picking and R. N. De Guzman, Mol. BioSyst., 2008, 4, 1176 DOI: 10.1039/B808271P

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