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Issue 9, 2021

Direct laser writing for cardiac tissue engineering: a microfluidic heart on a chip with integrated transducers

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Abstract

We have developed a microfluidic platform for engineering cardiac microtissues in highly-controlled microenvironments. The platform is fabricated using direct laser writing (DLW) lithography and soft lithography, and contains four separate devices. Each individual device houses a cardiac microtissue and is equipped with an integrated strain actuator and a force sensor. Application of external pressure waves to the platform results in controllable time-dependent forces on the microtissues. Conversely, oscillatory forces generated by the microtissues are transduced into measurable electrical outputs. We demonstrate the capabilities of this platform by studying the response of cardiac microtissues derived from human induced pluripotent stem cells (hiPSC) under prescribed mechanical loading and pacing. This platform will be used for fundamental studies and drug screening on cardiac microtissues.

Graphical abstract: Direct laser writing for cardiac tissue engineering: a microfluidic heart on a chip with integrated transducers

Supplementary files

Article information


Submitted
27 Oct 2020
Accepted
11 Mar 2021
First published
18 Mar 2021

Lab Chip, 2021,21, 1724-1737
Article type
Paper

Direct laser writing for cardiac tissue engineering: a microfluidic heart on a chip with integrated transducers

R. K. Jayne, M. Ç. Karakan, K. Zhang, N. Pierce, C. Michas, D. J. Bishop, C. S. Chen, K. L. Ekinci and A. E. White, Lab Chip, 2021, 21, 1724 DOI: 10.1039/D0LC01078B

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