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Issue 13, 2020
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High-throughput screening by droplet microfluidics: perspective into key challenges and future prospects

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Abstract

In two decades of development, impressive strides have been made for automating basic laboratory operations in droplet-based microfluidics, allowing the emergence of a new form of high-throughput screening and experimentation in nanoliter to femtoliter volumes. Despite advancements in droplet storage, manipulation, and analysis, the field has not yet been widely adapted for many high-throughput screening (HTS) applications. Broad adoption and commercial development of these techniques require robust implementation of strategies for the stable storage, chemical containment, generation of libraries, sample tracking, and chemical analysis of these small samples. We discuss these challenges for implementing droplet HTS and highlight key strategies that have begun to address these concerns. Recent advances in the field leave us optimistic about the future prospects of this rapidly developing technology.

Graphical abstract: High-throughput screening by droplet microfluidics: perspective into key challenges and future prospects

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Article information


Submitted
06 Apr 2020
Accepted
28 May 2020
First published
01 Jun 2020

Lab Chip, 2020,20, 2247-2262
Article type
Perspective
Author version available

High-throughput screening by droplet microfluidics: perspective into key challenges and future prospects

E. M. Payne, D. A. Holland-Moritz, S. Sun and R. T. Kennedy, Lab Chip, 2020, 20, 2247
DOI: 10.1039/D0LC00347F

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