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Issue 6, 2020

A microfluidic approach to micromembrane synthesis for complex release profiles of nanocarriers

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Abstract

Physically crosslinked microscale biomembranes synthesized from pure chitosan are designed and demonstrated for pH-triggered release of embedded functionalized mesoporous silica nanoparticles. Nanoparticle-loaded membranes are formed in a microfluidic channel at the junction between accurately controlled co-flowing streams to achieve highly tuneable membrane properties. After formation, the loaded membranes remain stable until contact with physiological acidic conditions, resulting in controlled nanoparticle release. Furthermore, nanoparticle-loaded membranes with complex layered architectures are synthesized using different flow schemes, thus enabling customized nanoparticle release profiles. These novel materials are well-suited for integration within small medical devices as well as off-chip applications.

Graphical abstract: A microfluidic approach to micromembrane synthesis for complex release profiles of nanocarriers

Supplementary files

Article information


Submitted
13 Jan 2020
Accepted
13 Feb 2020
First published
14 Feb 2020

Lab Chip, 2020,20, 1066-1071
Article type
Communication

A microfluidic approach to micromembrane synthesis for complex release profiles of nanocarriers

N. Jia, E. Rosella, E. Juère, R. Pouliot, F. Kleitz and J. Greener, Lab Chip, 2020, 20, 1066 DOI: 10.1039/D0LC00039F

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