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Issue 4, 2020
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Plasmonic nucleotide hybridization chip for attomolar detection: localized gold and tagged core/shell nanomaterials

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Abstract

We report a large amplification of surface plasmon signals for a double hybridization microarray chip assembly that bridges localized gold and detection probe-carrying-core/shell Fe3O4@Au nanoparticles for detection of as low as 80 aM miRNA-155 marker in solution. The plasmonic wavelength match of the gold shell with surface localized gold nanoparticles and the additional scattering band of the core/shell material in resonance with the incident 800 nm light source are the underlying factors for the observed remarkable analyte signal at ultra-low (10−18 order) concentrations.

Graphical abstract: Plasmonic nucleotide hybridization chip for attomolar detection: localized gold and tagged core/shell nanomaterials

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Article information


Submitted
20 Nov 2019
Accepted
22 Jan 2020
First published
22 Jan 2020

Lab Chip, 2020,20, 717-721
Article type
Communication

Plasmonic nucleotide hybridization chip for attomolar detection: localized gold and tagged core/shell nanomaterials

Z. H. Al Mubarak, G. Premaratne, A. Dharmaratne, F. Mohammadparast, M. Andiappan and S. Krishnan, Lab Chip, 2020, 20, 717
DOI: 10.1039/C9LC01150A

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