Jump to main content
Jump to site search

Issue 18, 2019
Previous Article Next Article

Acoustofluidic stick-and-play micropump built on foil for single-cell trapping

Author affiliations

Abstract

The majority of microfluidic devices nowadays are built on rigid or bulky substrates such as glass slides and polydimethylsiloxane (PDMS) slabs, and heavily rely on external equipment such as syringe pumps. Although a variety of micropumps have been developed in the past, few of them are suitable for flexible microfluidics or lab-on-a-foil systems. In this paper, stick-and-play acoustic micropump is built on thin and flexible plastic film by printing microstructures termed defended oscillating membrane equipped structures (DOMES) using two-photon polymerization. Specifically, this new micropump induces rectified flow upon the actuation of acoustic waves, and the flow patterns agree with simulation results very well. More importantly, the developed micropump has the capabilities to generate adjustable flow rates as high as 420 nL min−1, and does not suffer from problems such as bubble instability, gas dissolution, and undesired bubble-trapping that commonly occur in other forms of acoustic micropumps. Since the micropump works in stick-and-play mode, it is reusable after cleaning thanks to the easy separation of covers and substrates. Lastly, the developed micropump is applied for creating a self-pumped single-cell trapping device. The excellent trapping capability of the integrated device proves its potential for long-term studies of biological behaviors of individual cells for biomedical applications.

Graphical abstract: Acoustofluidic stick-and-play micropump built on foil for single-cell trapping

Back to tab navigation

Supplementary files

Article information


Submitted
22 May 2019
Accepted
05 Aug 2019
First published
05 Aug 2019

Lab Chip, 2019,19, 3045-3053
Article type
Paper

Acoustofluidic stick-and-play micropump built on foil for single-cell trapping

Y. Lin, Y. Gao, M. Wu, R. Zhou, D. Chung, G. Caraveo and J. Xu, Lab Chip, 2019, 19, 3045 DOI: 10.1039/C9LC00484J

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.


Social activity

Search articles by author

Spotlight

Advertisements