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Issue 13, 2019
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Self-aligning Tetris-Like (TILE) modular microfluidic platform for mimicking multi-organ interactions

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Abstract

Multi-organ perfusion systems offer the unique opportunity to mimic different physiological systemic interactions. However, existing multi-organ culture platforms have limited flexibility in specifying the culture conditions, device architectures, and fluidic connectivity simultaneously. Here, we report a modular microfluidic platform that addresses this limitation by enabling easy conversion of existing microfluidic devices into tissue and fluid control modules with self-aligning magnetic interconnects. This enables a ‘stick-n-play’ approach to assemble planar perfusion circuits that are amenable to both bioimaging-based and analytical measurements. A myriad of tissue culture and flow control TILE modules were successfully constructed with backward compatibility. Finally, we demonstrate applications in constructing recirculating multi-organ systems to emulate liver-mediated bioactivation of nutraceuticals and prodrugs to modulate their therapeutic efficacies in the context of atherosclerosis and cancer. This platform greatly facilitates the integration of existing organs-on-chip models to provide an intuitive and flexible way for users to configure different multi-organ perfusion systems.

Graphical abstract: Self-aligning Tetris-Like (TILE) modular microfluidic platform for mimicking multi-organ interactions

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Supplementary files

Article information


Submitted
15 Feb 2019
Accepted
25 May 2019
First published
30 May 2019

Lab Chip, 2019,19, 2178-2191
Article type
Paper

Self-aligning Tetris-Like (TILE) modular microfluidic platform for mimicking multi-organ interactions

L. J. Y. Ong, T. Ching, L. H. Chong, S. Arora, H. Li, M. Hashimoto, R. DasGupta, P. K. Yuen and Y. Toh, Lab Chip, 2019, 19, 2178
DOI: 10.1039/C9LC00160C

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