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Issue 14, 2019
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Enrichment of extracellular vesicles with lipid nanoprobe functionalized nanostructured silica

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Abstract

Nanoscale extracellular vesicles (nEVs) have recently demonstrated potential value in cancer diagnostics and treatment monitoring, but translation has been limited by technical challenges in nEV isolation. Thus, we have developed a one-step nEV isolation platform that utilizes nEV size-matched silica nanostructures and a surface-conjugated lipid nanoprobe with an integrated microfluidic mixer. The reported platform has 28.8% capture efficiency from pancreatic cancer plasma and can sufficiently enrich nEVs for simpler positive identification of point mutations, particularly KRAS, in nEV DNA from the plasma of pancreatic cancer patients.

Graphical abstract: Enrichment of extracellular vesicles with lipid nanoprobe functionalized nanostructured silica

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Supplementary files

Article information


Submitted
13 Dec 2018
Accepted
29 Apr 2019
First published
24 Jun 2019

Lab Chip, 2019,19, 2346-2355
Article type
Communication

Enrichment of extracellular vesicles with lipid nanoprobe functionalized nanostructured silica

Y. Wan, M. Maurer, H. He, Y. Xia, S. Hao, W. Zhang, N. S. Yee and S. Zheng, Lab Chip, 2019, 19, 2346
DOI: 10.1039/C8LC01359D

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