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Issue 23, 2017
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Enhanced surface acoustic wave cell sorting by 3D microfluidic-chip design

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Abstract

We demonstrate an acoustic wave driven microfluidic cell sorter that combines advantages of multilayer device fabrication with planar surface acoustic wave excitation. We harness the strong vertical component of the refracted acoustic wave to enhance cell actuation by using an asymmetric flow field to increase cell deflection. Precise control of the 3-dimensional flow is realized by topographical structures implemented on the top of the microchannel. We experimentally quantify the effect of the structure dimensions and acoustic parameter. The design attains cell sorting rates and purities approaching those of state of the art fluorescence-activated cell sorters with all the advantages of microfluidic cell sorting.

Graphical abstract: Enhanced surface acoustic wave cell sorting by 3D microfluidic-chip design

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Article information


Submitted
09 Jul 2017
Accepted
03 Oct 2017
First published
03 Oct 2017

This article is Open Access

Lab Chip, 2017,17, 4059-4069
Article type
Paper

Enhanced surface acoustic wave cell sorting by 3D microfluidic-chip design

W. L. Ung, K. Mutafopulos, P. Spink, R. W. Rambach, T. Franke and D. A. Weitz, Lab Chip, 2017, 17, 4059
DOI: 10.1039/C7LC00715A

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