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Issue 13, 2017
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Effects of diffusion and mixing pattern on microfluidic-assisted synthesis of chitosan/ATP nanoparticles

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Abstract

Chitosan (CHI) nanoparticles present promising applications in pharmaceutical and biomedical fields, including drug and gene delivery. Among different approaches, microfluidics emerges as a resourceful tool for nanoparticle production in low-cost, reproducible processes with predictable fluid dynamics. However, microfluidic-assisted synthesis of CHI nanoparticles has not been widely explored in the literature. In this context, we systematically investigated different process parameters that influence the synthesis of CHI/ATP nanoparticles. We highlight the effects and limitations of diffusion and distinct mixing patterns developed through the microchannels on the final physicochemical characteristics of CHI/ATP nanoparticles produced. To address these hurdles, here we describe a simple, feasible, and reproducible method for the production of CHI/ATP nanoparticles. This strategy enables the development of a continuous and homogeneous production process for CHI nanoparticles to be applied in the most varied fields of research.

Graphical abstract: Effects of diffusion and mixing pattern on microfluidic-assisted synthesis of chitosan/ATP nanoparticles

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Supplementary files

Article information


Submitted
18 Mar 2017
Accepted
29 May 2017
First published
01 Jun 2017

Lab Chip, 2017,17, 2281-2293
Article type
Paper

Effects of diffusion and mixing pattern on microfluidic-assisted synthesis of chitosan/ATP nanoparticles

A. C. S. N. Pessoa, C. C. Sipoli and L. G. de la Torre, Lab Chip, 2017, 17, 2281
DOI: 10.1039/C7LC00291B

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