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Issue 17, 2017
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Novel nanosensing technologies for exosome detection and profiling

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Abstract

Exosomes have recently emerged as highly promising cancer biomarkers because they are abundant in biofluids, carry proteins and RNA reflecting their originating cells and are stable over weeks. Beyond abundance and stability, detailed exosome analyses could be clinically useful for diagnosing and profiling cancers. Despite their clinical potential, simple, reliable and sensitive approaches for rapidly quantifying exosomes and their molecular information has been challenging. Therefore, there is a clear need to develop next-generation sensing technologies for exosome detection and analysis. In this critical review, we will describe three nanotechnology sensing platforms developed for analysis of exosomal proteins and RNAs directly from clinical specimens and discuss future development to facilitate their translation into routine clinical use.

Graphical abstract: Novel nanosensing technologies for exosome detection and profiling

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Article information


Submitted
07 Mar 2017
Accepted
18 Jul 2017
First published
18 Jul 2017

Lab Chip, 2017,17, 2892-2898
Article type
Critical Review

Novel nanosensing technologies for exosome detection and profiling

H. Im, K. Lee, R. Weissleder, H. Lee and C. M. Castro, Lab Chip, 2017, 17, 2892
DOI: 10.1039/C7LC00247E

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