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Issue 1, 2017
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Smartphone based hand-held quantitative phase microscope using the transport of intensity equation method

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Abstract

In order to realize high contrast imaging with portable devices for potential mobile healthcare, we demonstrate a hand-held smartphone based quantitative phase microscope using the transport of intensity equation method. With a cost-effective illumination source and compact microscope system, multi-focal images of samples can be captured by the smartphone’s camera via manual focusing. Phase retrieval is performed using a self-developed Android application, which calculates sample phases from multi-plane intensities via solving the Poisson equation. We test the portable microscope using a random phase plate with known phases, and to further demonstrate its performance, a red blood cell smear, a Pap smear and monocot root and broad bean epidermis sections are also successfully imaged. Considering its advantages as an accurate, high-contrast, cost-effective and field-portable device, the smartphone based hand-held quantitative phase microscope is a promising tool which can be adopted in the future in remote healthcare and medical diagnosis.

Graphical abstract: Smartphone based hand-held quantitative phase microscope using the transport of intensity equation method

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Supplementary files

Article information


Submitted
25 Oct 2016
Accepted
29 Nov 2016
First published
30 Nov 2016

Lab Chip, 2017,17, 104-109
Article type
Paper

Smartphone based hand-held quantitative phase microscope using the transport of intensity equation method

X. Meng, H. Huang, K. Yan, X. Tian, W. Yu, H. Cui, Y. Kong, L. Xue, C. Liu and S. Wang, Lab Chip, 2017, 17, 104
DOI: 10.1039/C6LC01321J

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