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Issue 9, 2016
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Selective plane illumination microscopy on a chip

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Abstract

Selective plane illumination microscopy can image biological samples at a high spatiotemporal resolution. Complex sample preparation and system alignment normally limit the throughput of the method. Using femtosecond laser micromachining, we created an integrated optofluidic device that allows obtaining continuous flow imaging, three-dimensional reconstruction and high-throughput analysis of large multicellular spheroids at a subcellular resolution.

Graphical abstract: Selective plane illumination microscopy on a chip

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Article information


Submitted
20 Jan 2016
Accepted
17 Mar 2016
First published
17 Mar 2016

This article is Open Access

Lab Chip, 2016,16, 1556-1560
Article type
Communication

Selective plane illumination microscopy on a chip

P. Paiè, F. Bragheri, A. Bassi and R. Osellame, Lab Chip, 2016, 16, 1556
DOI: 10.1039/C6LC00084C

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