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Issue 20, 2015
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Microfluidic vascularized bone tissue model with hydroxyapatite-incorporated extracellular matrix

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Abstract

Current in vitro systems mimicking bone tissues fail to fully integrate the three-dimensional (3D) microvasculature and bone tissue microenvironments, decreasing their similarity to in vivo conditions. Here, we propose 3D microvascular networks in a hydroxyapatite (HA)-incorporated extracellular matrix (ECM) for designing and manipulating a vascularized bone tissue model in a microfluidic device. Incorporation of HA of various concentrations resulted in ECM with varying mechanical properties. Sprouting angiogenesis was affected by mechanically modulated HA–extracellular matrix interactions, generating a model of vascularized bone microenvironment. Using this platform, we observed that hydroxyapatite enhanced angiogenic properties such as sprout length, sprouting speed, sprout number, and lumen diameter. This new platform integrates fibrin ECM with the synthetic bone mineral HA to provide in vivo-like microenvironments for bone vessel sprouting.

Graphical abstract: Microfluidic vascularized bone tissue model with hydroxyapatite-incorporated extracellular matrix

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Supplementary files

Article information


Submitted
22 Jun 2015
Accepted
05 Aug 2015
First published
06 Aug 2015

Lab Chip, 2015,15, 3984-3988
Article type
Communication
Author version available

Microfluidic vascularized bone tissue model with hydroxyapatite-incorporated extracellular matrix

N. Jusoh, S. Oh, S. Kim, J. Kim and N. L. Jeon, Lab Chip, 2015, 15, 3984
DOI: 10.1039/C5LC00698H

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