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Issue 5, 2015
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Micro-elastometry on whole blood clots using actuated surface-attached posts (ASAPs)

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Abstract

We present a novel technology for microfluidic elastometry and demonstrate its ability to measure stiffness of blood clots as they form. A disposable micro-capillary strip draws small volumes (20 μL) of whole blood into a chamber containing a surface-mounted micropost array. The posts are magnetically actuated, thereby applying a shear stress to the blood clot. The posts' response to magnetic field changes as the blood clot forms; this response is measured by optical transmission. We show that a quasi-static model correctly predicts the torque applied to the microposts. We experimentally validate the ability of the system to measure clot stiffness by correlating our system with a commercial thromboelastograph. We conclude that actuated surface-attached post (ASAP) technology addresses a clinical need for point-of-care and small-volume elastic haemostatic assays.

Graphical abstract: Micro-elastometry on whole blood clots using actuated surface-attached posts (ASAPs)

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Article information


Submitted
16 Dec 2014
Accepted
08 Jan 2015
First published
08 Jan 2015

Lab Chip, 2015,15, 1385-1393
Article type
Paper
Author version available

Micro-elastometry on whole blood clots using actuated surface-attached posts (ASAPs)

R. M. Judith, J. K. Fisher, R. C. Spero, B. L. Fiser, A. Turner, B. Oberhardt, R. M. Taylor, M. R. Falvo and R. Superfine, Lab Chip, 2015, 15, 1385
DOI: 10.1039/C4LC01478B

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