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Issue 5, 2015
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In vitro evaluation and in vivo demonstration of a biomimetic, hemocompatible, microfluidic artificial lung

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Abstract

Despite the promising potential of microfluidic artificial lungs, current designs suffer from short functional lifetimes due to surface chemistry and blood flow patterns that act to reduce hemocompatibility. Here, we present the first microfluidic artificial lung featuring a hemocompatible surface coating and a biomimetic blood path. The polyethylene-glycol (PEG) coated microfluidic lung exhibited a significantly improved in vitro lifetime compared to uncoated controls as well as consistent and significantly improved gas exchange over the entire testing period. Enabled by our hemocompatible PEG coating, we additionally describe the first extended (3 h) in vivo demonstration of a microfluidic artificial lung.

Graphical abstract: In vitro evaluation and in vivo demonstration of a biomimetic, hemocompatible, microfluidic artificial lung

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Article information


Submitted
29 Oct 2014
Accepted
07 Jan 2015
First published
08 Jan 2015

Lab Chip, 2015,15, 1366-1375
Article type
Paper
Author version available

In vitro evaluation and in vivo demonstration of a biomimetic, hemocompatible, microfluidic artificial lung

K. M. Kovach, M. A. LaBarbera, M. C. Moyer, B. L. Cmolik, E. van Lunteren, A. Sen Gupta, J. R. Capadona and J. A. Potkay, Lab Chip, 2015, 15, 1366
DOI: 10.1039/C4LC01284D

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