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Issue 24, 2014
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A simple microfluidic dispenser for single-microparticle and cell samples

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Abstract

Non-destructive isolation of single-cells has become an important need for many biology research laboratories; however, there is a lack of easily employed and inexpensive tools. Here, we present a single-particle sample delivery approach fabricated from simple, economical components that may address this need. In this, we employ unique flow and timing strategies to bridge the significant force and length scale differences inherent in transitioning from single particle isolation to delivery. Demonstrating this approach, we use an optical trap to isolate individual microparticles and red blood cells that are dispensed within separate 50 μl droplets off a microfluidic chip for collection into microscope slides or microtiter plates.

Graphical abstract: A simple microfluidic dispenser for single-microparticle and cell samples

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Publication details

The article was received on 24 Jul 2014, accepted on 03 Oct 2014 and first published on 06 Oct 2014


Article type: Paper
DOI: 10.1039/C4LC00863D
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Citation: Lab Chip, 2014,14, 4673-4679

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    A simple microfluidic dispenser for single-microparticle and cell samples

    A. Kasukurti, C. D. Eggleton, S. A. Desai, D. I. Disharoon and D. W. M. Marr, Lab Chip, 2014, 14, 4673
    DOI: 10.1039/C4LC00863D

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