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Issue 17, 2014
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Resonance-enhanced microfluidic impedance cytometer for detection of single bacteria

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Abstract

This paper reports on a novel impedance-based cytometer, which can detect and characterize sub-micrometer particles and cells passing through a microfluidic channel. The cytometer incorporates a resonator, which is constructed by means of a discrete inductor in series with the measurement electrodes in the microfluidic channel. The use of a resonator increases the sensitivity of the system in comparison to state-of-the-art devices. We demonstrate the functionality and sensitivity of the cytometer by discriminating E. coli and B. subtilis from beads of similar sizes by means of the resonance-enhanced phase shift of the current through the microfluidic channel. The phase shift can be correlated to size and dielectric properties of the measured objects.

Graphical abstract: Resonance-enhanced microfluidic impedance cytometer for detection of single bacteria

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Article information


Submitted
16 May 2014
Accepted
20 Jun 2014
First published
23 Jun 2014

Lab Chip, 2014,14, 3313-3324
Article type
Paper

Resonance-enhanced microfluidic impedance cytometer for detection of single bacteria

N. Haandbæk, O. With, S. C. Bürgel, F. Heer and A. Hierlemann, Lab Chip, 2014, 14, 3313
DOI: 10.1039/C4LC00576G

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