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Issue 17, 2014
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Approaching the in vitro clinical trial: engineering organs on chips

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Abstract

In vitro cell culture and animal models are the most heavily relied upon tools of the pharmaceutical industry. When these tools fail, the results are costly and have at times, proven deadly. One promising new tool to enhance preclinical development of drugs is Organs on Chips (OOCs), proposed as a clinically and physiologically relevant means of modeling health and disease. Bringing the patient from bedside to bench in this form requires that the design, build, and test of OOCs be founded in clinical observations and methods. By creating OOCs as models of the patient, the industry may be better positioned to evaluate medicinal therapeutics

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Article information


Submitted
04 Mar 2014
Accepted
28 Apr 2014
First published
15 May 2014

Lab Chip, 2014,14, 3181-3186
Article type
Frontier

Approaching the in vitro clinical trial: engineering organs on chips

A. K. Capulli, K. Tian, N. Mehandru, A. Bukhta, S. F. Choudhury, M. Suchyta and K. K. Parker, Lab Chip, 2014, 14, 3181
DOI: 10.1039/C4LC00276H

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