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Issue 1, 2014
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Miniaturized nuclear magnetic resonance platform for detection and profiling of circulating tumor cells

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Abstract

Accurate detection and profiling of circulating tumor cells (CTCs) is a highly sought after technology to improve cancer management. Such “liquid biopsies” could offer a non-invasive, repeatable window into each patient's tumor, facilitating early cancer diagnosis and treatment monitoring. The rarity of CTCs, approximated at 1 CTC for every billion peripheral blood cells, however, poses significant challenges to sensitive and reliable detection. We have recently developed a new micro-nuclear magnetic resonance (μNMR) platform for biosensing. Through the synergistic integration of microfabrication, nanosensors, and novel chemistries, the μNMR platform offers high detection sensitivity and point-of-care operation, overcoming technical barriers in CTC research. We herein review the μNMR technology with emphasis on its application to CTC detection. Recent advances in the sensing technology will be summarized, followed by the description of the dynamic interplay between our preclinical and clinical CTC studies.

Graphical abstract: Miniaturized nuclear magnetic resonance platform for detection and profiling of circulating tumor cells

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Publication details

The article was received on 20 May 2013, accepted on 26 Jun 2013 and first published on 27 Jun 2013


Article type: Tutorial Review
DOI: 10.1039/C3LC50621E
Lab Chip, 2014,14, 14-23

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    Miniaturized nuclear magnetic resonance platform for detection and profiling of circulating tumor cells

    C. M. Castro, A. A. Ghazani, J. Chung, H. Shao, D. Issadore, T. Yoon, R. Weissleder and H. Lee, Lab Chip, 2014, 14, 14
    DOI: 10.1039/C3LC50621E

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