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Issue 21, 2013
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Single cell detection using 3D magnetic rolled-up structures

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Abstract

A 3D rolled-up structure made of a SiO2 layer and a fishbone-like magnetic thin film was proposed here as a biosensor. The magnetoresistance (MR) measurement results of the sensor suggest that the presence of the stray field, which is induced by the magnetic nanoparticles, significantly increased the switching field. Comparing the performance of the 2D sensor and 3D sensor designed in this study, the response in switching field variation was 12.14% in the 2D sensor and 62.55% in the 3D sensor. The response in MR ratio variation was 4.55% in the 2D sensor and 82.32% in the 3D sensor. In addition, the design of the 3D sensor structure also helped to attract and trap a single magnetic cell due to its stronger stray field compared with the 2D structure. The 3D magnetic biosensor designed here can provide important information for future biochip research and applications.

Graphical abstract: Single cell detection using 3D magnetic rolled-up structures

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Publication details

The article was received on 15 Jun 2013, accepted on 02 Aug 2013 and first published on 05 Aug 2013


Article type: Paper
DOI: 10.1039/C3LC50721A
Citation: Lab Chip, 2013,13, 4225-4230

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    Single cell detection using 3D magnetic rolled-up structures

    T. Ger, H. Huang, C. Huang and M. Lai, Lab Chip, 2013, 13, 4225
    DOI: 10.1039/C3LC50721A

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