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Issue 7, 2013
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A biopharmaceutical plant on a chip: continuous micro-devices for the production of monoclonal antibodies

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Abstract

We report a proof-of-principle for the use of micro-devices as continuous bioreactors for the production of monoclonal antibodies. We culture CHO cells on the surface of PMMA “zigzag” channels textured with semi-spherical cavities coated with fibronectin, observing steady-state productivities 100 times higher than those observed in full scale systems.

Graphical abstract: A biopharmaceutical plant on a chip: continuous micro-devices for the production of monoclonal antibodies

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Supplementary files

Article information


Submitted
02 Dec 2012
Accepted
23 Jan 2013
First published
11 Feb 2013

Lab Chip, 2013,13, 1243-1246
Article type
Communication

A biopharmaceutical plant on a chip: continuous micro-devices for the production of monoclonal antibodies

L. D. Garza-García, L. M. Carrillo-Cocom, D. Araiz-Hernández, P. Soto-Vázquez, J. López-Meza, E. J. Tapia-Mejía, S. Camacho-León, E. García-López, C. A. Rodríguez-González and M. M. Alvarez, Lab Chip, 2013, 13, 1243 DOI: 10.1039/C3LC50104C

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