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Issue 8, 2013
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Measuring cell mechanics by optical alignment compression cytometry

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Abstract

To address the need for a high throughput, non-destructive technique for measuring individual cell mechanical properties, we have developed optical alignment compression (OAC) cytometry. OAC combines hydrodynamic drag in an extensional flow microfluidic device with optical forces created with an inexpensive diode laser to induce measurable deformations between compressed cells. In this, a low-intensity linear optical trap aligns incoming cells with the flow stagnation point allowing hydrodynamic drag to induce deformation during cell–cell interaction. With this novel approach, we measure cell mechanical properties with a throughput that improves significantly on current non-destructive individual cell testing methods.

Graphical abstract: Measuring cell mechanics by optical alignment compression cytometry

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Supplementary files

Article information


Submitted
04 Sep 2012
Accepted
05 Feb 2013
First published
08 Feb 2013

Lab Chip, 2013,13, 1571-1577
Article type
Paper

Measuring cell mechanics by optical alignment compression cytometry

K. B. Roth, C. D. Eggleton, K. B. Neeves and D. W. M. Marr, Lab Chip, 2013, 13, 1571
DOI: 10.1039/C3LC41253A

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