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Issue 5, 2013
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Rapid and specific electrochemical detection of prostate cancer cells using an aperture sensor array

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Abstract

A rapid, simple and specific cancer cell counting sensor would allow for early detection and better disease management. We have developed a novel cell counting device that can specifically count 125 prostate cancer cells in both complex media with serum and a mixed cell population containing non-target cells within 15 min. The microfabricated glass chip with exposed gold apertures utilizes the anti-EpCAM antibody to selectively count prostate cancer cells via differential pulse voltammetry. The newly developed sensor exhibits excellent sensitivity and selectivity. The cells remain viable throughout the counting process and can be used for further analysis. This device could have utility for future applications in early stage cancer diagnosis.

Graphical abstract: Rapid and specific electrochemical detection of prostate cancer cells using an aperture sensor array

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Supplementary files

Article information


Submitted
14 Sep 2012
Accepted
21 Dec 2012
First published
03 Jan 2013

Lab Chip, 2013,13, 940-946
Article type
Paper

Rapid and specific electrochemical detection of prostate cancer cells using an aperture sensor array

M. Moscovici, A. Bhimji and S. O. Kelley, Lab Chip, 2013, 13, 940
DOI: 10.1039/C2LC41049D

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