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Issue 12, 2012
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Droplet microfluidics for high-throughput biological assays

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Abstract

Droplet microfluidics offers significant advantages for performing high-throughput screens and sensitive assays. Droplets allow sample volumes to be significantly reduced, leading to concomitant reductions in cost. Manipulation and measurement at kilohertz speeds enable up to 108 samples to be screened in one day. Compartmentalization in droplets increases assay sensitivity by increasing the effective concentration of rare species and decreasing the time required to reach detection thresholds. Droplet microfluidics combines these powerful features to enable currently inaccessible high-throughput screening applications, including single-cell and single-molecule assays.

Graphical abstract: Droplet microfluidics for high-throughput biological assays

  • This article is part of the themed collection: Focus on USA
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Article information


Submitted
22 Nov 2011
Accepted
11 Jan 2012
First published
09 Feb 2012

Lab Chip, 2012,12, 2146-2155
Article type
Critical Review

Droplet microfluidics for high-throughput biological assays

M. T. Guo, A. Rotem, J. A. Heyman and D. A. Weitz, Lab Chip, 2012, 12, 2146
DOI: 10.1039/C2LC21147E

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