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Issue 6, 2012
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Hydrodynamic shearing of DNA in a polymeric microfluidic device

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Abstract

With the advent of next-generation sequencing (NGS) systems and the associated high throughput they afford, the input to these machines requires manageable lengths of fragments (∼1000 bp) produced from chromosomal DNAs. Therefore, it is critical to develop devices that can shear DNA in a controlled fashion. We report a polymer-based microfluidic device that establishes an efficient and inexpensive platform with performance comparable to a commercially available bench-top system.

Graphical abstract: Hydrodynamic shearing of DNA in a polymeric microfluidic device

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Article information


Submitted
17 Nov 2011
Accepted
26 Jan 2012
First published
27 Jan 2012

Lab Chip, 2012,12, 1044-1047
Article type
Communication

Hydrodynamic shearing of DNA in a polymeric microfluidic device

I. V. Nesterova, M. L. Hupert, M. A. Witek and S. A. Soper, Lab Chip, 2012, 12, 1044
DOI: 10.1039/C2LC21122J

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