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Issue 4, 2012
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Single-vesicle estimation of ATP-binding cassette transporters in microfluidic channels

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Abstract

We have developed a method to analyze the substrate transport of ATP-binding cassette (ABC) transporters, which are associated with drug resistance in tumor cells. Our microfluidic method is well suited to the single-vesicle estimation of substrate transport and the rapid drug screening of ABC transporters. Using this method, we have demonstrated, for the first time, the analysis of substrate transport by a single transporter and performed drug-inhibition experiments in less than 3 h.

Graphical abstract: Single-vesicle estimation of ATP-binding cassette transporters in microfluidic channels

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Submitted
01 Nov 2011
Accepted
30 Nov 2011
First published
30 Nov 2011

Lab Chip, 2012,12, 702-704
Article type
Communication

Single-vesicle estimation of ATP-binding cassette transporters in microfluidic channels

H. Sasaki, R. Kawano, T. Osaki, K. Kamiya and S. Takeuchi, Lab Chip, 2012, 12, 702
DOI: 10.1039/C2LC21058D

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