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Issue 8, 2012
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DNA electrophoresis in a nanofence array

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Abstract

We present the design and implementation of an oxidized silicon “nanofence array” for long DNA electrophoresis. The device consists of a periodic array of post-filled regions (the nanofences) alternating with empty channel regions. Even in this prototype version, the nanofence array provides the resolving power of a hexagonal nanopost array without requiring any direct-write nanopatterning steps such as electron-beam lithography. Through detailed single molecule investigations, we demonstrate that the origin of the resolving power of the nanofence array is not a reduction in band broadening, which might be expected from the theories for DNA electrophoresis in post arrays. Rather, the enhanced stretching of the hooked DNA by the uniform electric field between nanofences increases the efficiency of the collisions.

Graphical abstract: DNA electrophoresis in a nanofence array

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Publication details

The article was received on 04 Jan 2012, accepted on 16 Feb 2012 and first published on 17 Feb 2012


Article type: Paper
DOI: 10.1039/C2LC00016D
Lab Chip, 2012,12, 1463-1470

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    DNA electrophoresis in a nanofence array

    S. Park, D. W. Olson and K. D. Dorfman, Lab Chip, 2012, 12, 1463
    DOI: 10.1039/C2LC00016D

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