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Issue 9, 2012
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Walking nanothermometers: spatiotemporal temperature measurement of transported acidic organelles in single living cells

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Abstract

We fabricated fluorescent nanoparticles which monitor temperature changes without sensitivity to pH (4–10) and ionic strength (0–500 mM). The nanothermometers spontaneously enter living HeLa cells via endocytosis, enclosed in acidic organelles, i.e., endosome/lysosome, and then transported along microtubules in a temperature-dependent manner, working as “walking nanothermometers”.

Graphical abstract: Walking nanothermometers: spatiotemporal temperature measurement of transported acidic organelles in single living cells

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Publication details

The article was received on 04 Jan 2012, accepted on 05 Mar 2012 and first published on 08 Mar 2012


Article type: Communication
DOI: 10.1039/C2LC00014H
Citation: Lab Chip, 2012,12, 1591-1593

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    Walking nanothermometers: spatiotemporal temperature measurement of transported acidic organelles in single living cells

    K. Oyama, M. Takabayashi, Y. Takei, S. Arai, S. Takeoka, S. Ishiwata and M. Suzuki, Lab Chip, 2012, 12, 1591
    DOI: 10.1039/C2LC00014H

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