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Issue 1, 2012
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Isolation of prostate tumor initiating cells (TICs) through their dielectrophoretic signature

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Abstract

In this study, the dielectrophoretic response of prostate tumor initiating cells (TICs) was investigated in a microfluidic system utilizing contactless dielectrophoresis (cDEP). The dielectrophoretic response of prostate TICs was observed to be distinctively different than that for non-TICs, enabling them to be sorted using cDEP. Culturing the sorted TICs generated spheroids, indicating that they were indeed initiating cells. This study presents the first marker-free TIC separation from non-TICs utilizing their electrical fingerprints through dielectrophoresis.

Graphical abstract: Isolation of prostate tumor initiating cells (TICs) through their dielectrophoretic signature

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Article information


Submitted
29 Jul 2011
Accepted
20 Oct 2011
First published
09 Nov 2011

Lab Chip, 2012,12, 182-189
Article type
Paper

Isolation of prostate tumor initiating cells (TICs) through their dielectrophoretic signature

A. Salmanzadeh, L. Romero, H. Shafiee, R. C. Gallo-Villanueva, M. A. Stremler, S. D. Cramer and R. V. Davalos, Lab Chip, 2012, 12, 182
DOI: 10.1039/C1LC20701F

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