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Issue 13, 2011
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Pumping-induced perturbation of flow in microfluidic channels and its implications for on-chip cell culture

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Abstract

We study the rate of response to changes in the rate of flow and the perturbations in flow in polydimethylsiloxane (PDMS) microfluidic chips that are subjected to several common flow-control systems. We find that the flow rate of liquid delivered from a syringe pump equipped with a glass syringe responds faster to the changes in the conditions of flow than the same liquid delivered from a plastic syringe; and the rate of flow delivered from compressed air responds faster than that from a glass syringe. We discover that the rate of flow that is driven by a syringe pump and regulated by an integrated pneumatic valve responds even faster, but this flow-control method is characterized by large perturbations. We also examine the possible effects of these large perturbations on NIH 3T3 cells in microfluidic channels and find that they could cause the detachment of NIH 3T3 cells in the microchannels.

Graphical abstract: Pumping-induced perturbation of flow in microfluidic channels and its implications for on-chip cell culture

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Publication details

The article was received on 01 Oct 2010, accepted on 21 Apr 2011 and first published on 23 May 2011


Article type: Technical Note
DOI: 10.1039/C0LC00466A
Citation: Lab Chip, 2011,11, 2288-2294

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    Pumping-induced perturbation of flow in microfluidic channels and its implications for on-chip cell culture

    J. Zhou, K. Ren, W. Dai, Y. Zhao, D. Ryan and H. Wu, Lab Chip, 2011, 11, 2288
    DOI: 10.1039/C0LC00466A

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