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Issue 2, 2011
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Particle sorting using a porous membrane in a microfluidic device

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Abstract

Porous membranes have been fabricated based on the development of the perforated membrane mold [Y. Luo and R. N. Zare, Lab Chip, 2008, 8, 1688–1694] to create a single filter that contains multiple pore sizes ranging from 6.4 to 16.6 µm inside a monolithic three-dimensional poly(dimethylsiloxane) microfluidic structure. By overlapping two filters we are able to achieve smaller pore size openings (2.5 to 3.3 µm). This filter operates without any detectable irreversible clogging, which is achieved using a cross-flow placed in front of each filtration section. The utility of a particle-sorting device that contains this filter is demonstrated by separating polystyrene beads of different diameters with an efficiency greater than 99.9%. Additionally, we demonstrate the effectiveness of this particle-sorting device by separating whole blood samples into white blood cells and red blood cells with platelets.

Graphical abstract: Particle sorting using a porous membrane in a microfluidic device

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Publication details

The article was received on 16 Jun 2010, accepted on 05 Oct 2010 and first published on 08 Nov 2010


Article type: Paper
DOI: 10.1039/C0LC00121J
Lab Chip, 2011,11, 238-245

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    Particle sorting using a porous membrane in a microfluidic device

    H. Wei, B. Chueh, H. Wu, E. W. Hall, C. Li, R. Schirhagl, J. Lin and R. N. Zare, Lab Chip, 2011, 11, 238
    DOI: 10.1039/C0LC00121J

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