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Issue 20, 2010
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Surface-modified microprojection arrays for intradermal biomarker capture, with low non-specific protein binding

Simon R. Corrie,*a   Germain J. P. Fernando,a   Michael L. Crichton,a   Marion E. G. Brunck,a   Chris D. Andersonb  and  Mark A. F. Kendall*ac  
Author affiliations

* Corresponding authors

a The University of Queensland, Australian Institute for Bioengineering and Nanotechnology, St Lucia, QLD, Australia
E-mail: s.corrie1@uq.edu.au
Fax: +61 7 3346 3973
Tel: +61 7 3346 4209

b Department of Clinical and Experimental Medicine, Division of Dermatology, Linköping University, Linköping, Sweden

c The University of Queensland, Diamantina Institute for Cancer, Immunology and Metabolic Medicine, Princess Alexandra Hospital, Ipswich Rd, Woolloongabba, QLD, Australia

Abstract

Minimally invasive biosensors are of great interest for rapid detection of disease biomarkers for diagnostic screening at the point-of-care. Here we introduce a device which extracts disease-specific biomarkers directly from the upper dermis, without the needle and syringe or resource-intensive blood processing. Using antigen-specific antibodies raised in mice as a model system, we confirm the analytical specificity and sensitivity of the antibody capture and extraction in comparison to the conventional methods based on needle/syringe blood draw followed by processing and antigen-specific ELISAs.

Graphical abstract: Surface-modified microprojection arrays for intradermal biomarker capture, with low non-specific protein binding

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Article information

https://doi.org/10.1039/C0LC00068J
Submitted
03 Jun 2010
Accepted
06 Aug 2010
First published
31 Aug 2010
Lab Chip, 2010,10, 2655-2658
Article type
Communication
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Surface-modified microprojection arrays for intradermal biomarker capture, with low non-specific protein binding

S. R. Corrie, G. J. P. Fernando, M. L. Crichton, M. E. G. Brunck, C. D. Anderson and M. A. F. Kendall, Lab Chip, 2010, 10, 2655
DOI: 10.1039/C0LC00068J

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