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Issue 14, 2010
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A prefilled, ready-to-use electrophoresis based lab-on-a-chip device for monitoring lithium in blood

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Abstract

We present the Medimate MultireaderR, the first point-of-care lab on a chip device that is based on capillary electrophoresis. It employs disposable pre-filled microfluidic chips with closed electrode reservoirs and a single sample opening. Several technological innovations allow operation with closed reservoirs, which is essential for reliable point-of-care operation. The chips are inserted into a hand-held analyzer. In the present application, the device is used to measure the lithium concentration in blood. Lithium is quantified by conductivity detection after separation from other blood ions. Measurements in patients show good accuracy and precision, and there is no difference between the results obtained by skilled and non-skilled operators. This point-of-care device shows great promise as a platform for the determination of ionic substances in diagnostics or environmental analysis.

Graphical abstract: A prefilled, ready-to-use electrophoresis based lab-on-a-chip device for monitoring lithium in blood

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Article information


Submitted
04 Mar 2010
Accepted
10 May 2010
First published
07 Jun 2010

Lab Chip, 2010,10, 1799-1806
Article type
Paper

A prefilled, ready-to-use electrophoresis based lab-on-a-chip device for monitoring lithium in blood

A. Floris, S. Staal, S. Lenk, E. Staijen, D. Kohlheyer, J. Eijkel and A. van den Berg, Lab Chip, 2010, 10, 1799
DOI: 10.1039/C003899G

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