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Issue 3, 2010
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Lithographically patterned siliconnanowire arrays for matrix free LDI-TOF/MS analysis of lipids

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Abstract

Silicon nanowire arrays were patterned onto silicon chips by a combination of lithography and chemical vapor deposition using the vapor-liquid-solid growth method. Thus, highly reproducible sample deposition zones were obtained that were used for laser desorption ionization (LDI) mass spectrometric analysis of lipidic species with lithium salts as dopants. Using a conventional UV laser (337 nm), hydrocarbons and numerous lipids (triglycerides, diglycerides, wax esters) could be effectively lithiated yielding [M + Li]+ ions. Upon doping with lithium hydroxide the SiNW arrays yielded high signal-to-noise ratios with low limits of detection (e.g. 750 pg tripalmitin on target with S/N 5) and efficient ionization for a range of fatty acids (FA), mono-, di- and triglycerides and hydrocarbons (HC), in the form of [FA − H + 2Li]+, [mono- or diglyceride − H2O + Li]+, or [triglyceride + Li]+ and [HC + Li]+, respectively. It is expected that these chips will find a broad range of applications in the analysis of natural compounds and food control.

Graphical abstract: Lithographically patterned silicon nanowire arrays for matrix free LDI-TOF/MS analysis of lipids

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Publication details

The article was received on 03 Jul 2009, accepted on 14 Oct 2009 and first published on 19 Nov 2009


Article type: Paper
DOI: 10.1039/B913212K
Lab Chip, 2010,10, 320-325

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    Lithographically patterned silicon nanowire arrays for matrix free LDI-TOF/MS analysis of lipids

    A. Muck, T. Stelzner, U. Hübner, S. Christiansen and A. Svatoš, Lab Chip, 2010, 10, 320
    DOI: 10.1039/B913212K

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