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Issue 20, 2009
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Highly efficient chemoselective N-acylation with water microreaction system in the absence of catalyst

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Abstract

A high-speed, highly efficient chemoselective N-acylation by anhydride was achieved in the absence of catalyst for exothermic (ΔH > 0) and endothermic (ΔH < 0) acylation of various amines and anilines with the microreaction system of ambient water (µ-onH2O) and subcritical water (µ-subH2O), where the desired N-acylated products are chemoselectively obtained with high yield(s) and excellent selectivity (>95%).

Graphical abstract: Highly efficient chemoselective N-acylation with water microreaction system in the absence of catalyst

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Article information


Submitted
07 Jul 2009
Accepted
24 Aug 2009
First published
07 Sep 2009

Lab Chip, 2009,9, 2877-2880
Article type
Communication

Highly efficient chemoselective N-acylation with water microreaction system in the absence of catalyst

M. Sato, K. Matsushima, H. Kawanami, M. Chatterjee, T. Yokoyama, Y. Ikuhsima and T. M. Suzuki, Lab Chip, 2009, 9, 2877
DOI: 10.1039/B913515D

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