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Issue 12, 2006

Ultrasonic standing wave manipulation technology integrated into a dielectrophoretic chip

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Abstract

Several cell-based biological applications in microfluidic systems require simultaneous high-throughput and individual handling of cells or other bioparticles. Available chip-based tools for contactless manipulation are designed for either high-precision handling of individual particles, or high-throughput handling of ensembles of particles. In order to simultaneously perform both, we have combined two manipulation technologies based on ultrasonic standing waves (USWs) and dielectrophoresis (DEP) in a microfluidic chip. The principle is based on the competition between long-range ultrasonic forces, short-range dielectrophoretic forces and viscous drag forces from the fluid flow. The ultrasound is coupled into the microchannel resonator by an external transducer with a refractive element placed on top of the chip, thereby allowing transmission light microscopy to continuously monitor the biological process. The DEP manipulation is generated by an electric field between co-planar microelectrodes placed on the bottom surface of the fluid channel. We demonstrate flexible and gentle elementary manipulation functions by the use of USWs and linear or curved DEP deflector elements that can be used in high-throughput biotechnology applications of individual cells.

Graphical abstract: Ultrasonic standing wave manipulation technology integrated into a dielectrophoretic chip

Article information


Submitted
23 Dec 2005
Accepted
22 Aug 2006
First published
11 Sep 2006

Lab Chip, 2006,6, 1537-1544
Article type
Paper

Ultrasonic standing wave manipulation technology integrated into a dielectrophoretic chip

M. Wiklund, C. Günther, R. Lemor, M. Jäger, G. Fuhr and H. M. Hertz, Lab Chip, 2006, 6, 1537 DOI: 10.1039/B612064B

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