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Issue 4, 2005
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A MALDI-chip integrated system with a monitoring window

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The integration of a monitoring port along the microfluidic path of a MALDI-chip integrated device is described. Optimization of the microreactor design allows longer reaction and measuring times. The Schiff base reaction between 4-tert-butylaniline (1) and 4-tert-butylbenzaldehyde (2) in ethanol was carried out on-chip in the MALDI ionization chamber and the formed imine 3 was detected in real time, demonstrating the feasibility of the “monitoring window” approach. This preliminary result opens the way to on-chip kinetic studies by MALDI-MS, by opening multiple monitoring windows along the microchannel.

Graphical abstract: A MALDI-chip integrated system with a monitoring window

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Article information

17 Dec 2004
07 Feb 2005
First published
16 Feb 2005

Lab Chip, 2005,5, 378-381
Article type

A MALDI-chip integrated system with a monitoring window

M. Brivio, N. R. Tas, M. H. Goedbloed, H. J. G. E. Gardeniers, W. Verboom, A. van den Berg and D. N. Reinhoudt, Lab Chip, 2005, 5, 378
DOI: 10.1039/B418986H

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