Issue 4, 2005
From the journal:

Lab on a Chip

A MALDI-chip integrated system with a monitoring window

Monica Brivio,a   Niels R. Tas,b   Martijn H. Goedbloed,b   Han J. G. E. Gardeniers,b   Willem Verboom,*a   Albert van den Bergb  and  David N. Reinhoudt*a  

* Corresponding authors

a Laboratory of Supramolecular Chemistry and Technology, MESA+ Institute for Nanotechnology, University of Twente, P.O. Box 217, Enschede, The Netherlands
E-mail: w.verboom@utwente.nl
Fax: +31 (0)53 4894645
Tel: +31 (0)53 4892980

b BIOS Lab-on-a-chip Group, MESA+ Institute for Nanotechnology, University of Twente, P.O. Box 217, Enschede, The Netherlands
Fax: +31 (0)53 4893595
Tel: +31 (0)53 4894356

Abstract

The integration of a monitoring port along the microfluidic path of a MALDI-chip integrated device is described. Optimization of the microreactor design allows longer reaction and measuring times. The Schiff base reaction between 4-tert-butylaniline (1) and 4-tert-butylbenzaldehyde (2) in ethanol was carried out on-chip in the MALDI ionization chamber and the formed imine 3 was detected in real time, demonstrating the feasibility of the “monitoring window” approach. This preliminary result opens the way to on-chip kinetic studies by MALDI-MS, by opening multiple monitoring windows along the microchannel.

Graphical abstract: A MALDI-chip integrated system with a monitoring window

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Article information

DOI
https://doi.org/10.1039/B418986H
Article type
Communication
Submitted
17 Dec 2004
Accepted
07 Feb 2005
First published
16 Feb 2005

Lab Chip, 2005,5, 378-381

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A MALDI-chip integrated system with a monitoring window

M. Brivio, N. R. Tas, M. H. Goedbloed, H. J. G. E. Gardeniers, W. Verboom, A. van den Berg and D. N. Reinhoudt, Lab Chip, 2005, 5, 378 DOI: 10.1039/B418986H

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