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Issue 4, 2002
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A pressure driven injection system for an ultra-flat chromatographic microchannel

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Abstract

A pressure-actuated on-chip injection system has been developed that is compatible with shallow microchannels with a very large aspect ratio, i.e. 1 μm deep and up to 1000 μm wide. Such channels offer potential advantages in the miniaturisation of liquid chromatography and other separation methods as they allow high loadability and low sample dispersion at the same time. Computational fluid dynamics simulations were performed to predict the flow profiles and the transport of a sample in the system and to justify the injection principle. Based on these simulations, a prototype integrated into a chip for hydrodynamic chromatography has been realised and tested experimentally. The performance of the device is satisfactory and the results are in qualitative agreement with the numerical models.

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Publication details

The article was received on 17 Jul 2002, accepted on 25 Sep 2002 and first published on 15 Oct 2002


Article type: Paper
DOI: 10.1039/B206932F
Lab Chip, 2002,2, 235-241

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    A pressure driven injection system for an ultra-flat chromatographic microchannel

    E. Chmela, M. T. Blom, (. J. G. E. Gardeniers, A. V. D. Berg and R. Tijssen, Lab Chip, 2002, 2, 235
    DOI: 10.1039/B206932F

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