Issue 2, 2002
From the journal:

Lab on a Chip

1,4-Addition of enolates to α,β-unsaturated ketones within a micro reactor

Charlotte Wiles,a   Paul Watts,a   Stephen J. Haswell*a  and  Esteban Pombo-Villarb  

* Corresponding authors

a Department of Chemistry, Faculty of Science and the Environment, University of Hull, Cottingham Road, Hull, UK
E-mail: s.j.haswell@hull.ac.uk
Fax: +44 (0)1482 466416
Tel: +44 (0)1482 465475

b Nervous Systems Research, WSJ-386.07.15, Novartis Pharma Ltd, Basel, Switzerland

Abstract

We demonstrate the formation of a series of diketone enolates and their subsequent reaction with α,β-unsaturated carbonyl compounds in order to prepare a variety of Michael adducts. In all cases, the conversions observed within a micro reactor were greater than those obtained in batch.

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Article information

DOI
https://doi.org/10.1039/B202210A
Article type
Communication
Submitted
04 Mar 2002
Accepted
28 Mar 2002
First published
19 Apr 2002

Lab Chip, 2002,2, 62-64

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1,4-Addition of enolates to α,β-unsaturated ketones within a micro reactor

C. Wiles, P. Watts, S. J. Haswell and E. Pombo-Villar, Lab Chip, 2002, 2, 62 DOI: 10.1039/B202210A

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