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Issue 38, 2012
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An ionic liquid-modified nano-vehicle to construct nano-models of catalase to target mitochondria

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Abstract

A new functional ionic liquid (IL) (IL = 4-acetyl-N-propenylpyridinium hexafluorophosphate) and methoxy poly(ethylene glycol) (PEG)-modified central hollow nano-vehicle (SiO2@IL–PEG) was synthesized and assembled with Mn(II) complexes, leading to two new kinds of nano-mimics of catalase. In vitro assay results show that the synthesized nano-mimics of catalase can decrease the oxygen consumption and mitochondria potential, which leads to effective inhibition of the proliferation of HepG-2 cells. Taken together, this study demonstrates that the ionic liquid and PEG-modified nano-vehicle is a good carrier of nano-models of catalase to target mitochondria, which would give a new path to develop mediators of cancer progression and the metabolite of oxygen.

Graphical abstract: An ionic liquid-modified nano-vehicle to construct nano-models of catalase to target mitochondria

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Supplementary files

Article information


Submitted
04 Jul 2012
Accepted
10 Aug 2012
First published
13 Aug 2012

J. Mater. Chem., 2012,22, 20299-20304
Article type
Paper

An ionic liquid-modified nano-vehicle to construct nano-models of catalase to target mitochondria

X. Yang, Q. Chen, M. Kong, L. Qu, Z. Geng and Z. Wang, J. Mater. Chem., 2012, 22, 20299
DOI: 10.1039/C2JM34354A

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