Issue 14, 2012
From the journal:

Journal of Materials Chemistry

The preparation of functionalized graphene oxide for targeted intracellular delivery of siRNA†

Xiaoying Yang,*a   Gaoli Niu,b   Xiufen Cao,a   Yuku Wen,b   Rong Xiang,*c   Hongquan Duana  and  Yongsheng Chen*d  

* Corresponding authors

a Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics (Theranostics), School of Pharmacy, Basic Medical Research Center, Tianjin Medical University, Tianjin 300070, China
E-mail: yangxiaoying@tijmu.edu.cn
Fax: +86 (22) 2349-9992
Tel: +86 (22) 2350-0693

b Liaoning Medical University Affiliated No.1 Hospital, Liaoning 121001, China

c Department of Immunology, College of Medicine, Key Laboratory of Bioactive Materials, Ministry of Education, Nankai University, Tianjin 300071, China
E-mail: rxiang@nankai.edu.cn

d Center for Nanoscale Science and Technology and Key Laboratory of Functional Polymer Materials, Institute of Polymer Chemistry, College of Chemistry, Nankai University, Tianjin 300071, China
E-mail: yschen99@nankai.edu.cn

Abstract

Functionalized graphene oxide (GO) for the targeted intracellular delivery of hTERT siRNA was prepared by conjugating GO with polyethylene glycol (PEG) and folic acid, followed by the loading of siRNA with the aid of 1-pyrenemethylamine hydrochloride via π–π stacking. It was found that it could target the HeLa in vitro and the transfected hTERT siRNA could knockdown the protein expression level and mRNA level efficiently.

Graphical abstract: The preparation of functionalized graphene oxide for targeted intracellular delivery of siRNA

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Article information

DOI
https://doi.org/10.1039/C2JM14718A
Article type
Paper
Submitted
22 Sep 2011
Accepted
07 Feb 2012
First published
24 Feb 2012

J. Mater. Chem., 2012,22, 6649-6654

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The preparation of functionalized graphene oxide for targeted intracellular delivery of siRNA

X. Yang, G. Niu, X. Cao, Y. Wen, R. Xiang, H. Duan and Y. Chen, J. Mater. Chem., 2012, 22, 6649 DOI: 10.1039/C2JM14718A

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