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Issue 5, 2012
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pH-responsive water soluble smart vesicles containing a bis(styryl)benzene derivative for two-photon microscopy imaging

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Abstract

We report self-assembled polymeric nanovesicles composed of 1,4-bis{4′-[N,N-bis(6′′-trimethylammoniumhexyl)amino]styryl}benzene tetrabromide (C1), poly[(ethylene oxide)-block-(sodium 2-acrylamido-2-methyl-1-propane sulfonate)] (Em-An), and hexadecyltrimethylammonium bromide (C16). Transmission electron microscopy (TEM) micrographs confirm the vesicular bilayer structures and atomic force microscopy (AFM) images show that the C1/Em-An/C16 complexes form spherical nanostructures with a particle size ranging from 40 to 80 nm. The encapsulation of C1 inside the nanovesicles enhances ∼2-fold the fluorescence quantum yield (η) and two-photon action cross-section (ηδ, where δ is the two-photon absorption cross-section), and allows internalization into the cells, as revealed by the bright two-photon microscopy (TPM) images of human cervical epithelioid carcinoma (HeLa) cells labeled with the nanovesicles. Moreover, nanovesicles containing a chemotherapeutic drug and a neutral molecule can also be prepared. Furthermore, the C1/vesicular complex is disassembled under acidic conditions, highlighting its potential as a pH-responsive smart nanocarrier for the intracellular drug delivery. These results suggest a new possibility of using nanovesicles as efficient two-photon probes for TPM imaging and possibly as nanocarriers for intracellular drug delivery.

Graphical abstract: pH-responsive water soluble smart vesicles containing a bis(styryl)benzene derivative for two-photon microscopy imaging

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Publication details

The article was received on 21 Sep 2011, accepted on 14 Nov 2011 and first published on 06 Dec 2011


Article type: Paper
DOI: 10.1039/C1JM14693A
Citation: J. Mater. Chem., 2012,22, 1977-1984

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    pH-responsive water soluble smart vesicles containing a bis(styryl)benzene derivative for two-photon microscopy imaging

    O. K. Nag, C. S. Lim, B. L. Nguyen, B. Kim, J. Jang, J. H. Han, B. R. Cho and H. Y. Woo, J. Mater. Chem., 2012, 22, 1977
    DOI: 10.1039/C1JM14693A

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