This review highlights recent advanced researches on the assembly of various metallic nanostructures by oligonucleotide and plasmid DNA. The obtained DNA–nanoconjugates show many unique and attractive properties, while this review focuses on their properties related to SERS detection. The applications of DNA-based assemblies in SERS detections were fully commented upon, for the detection of DNA, proteins, small molecules, and metallic ions. Finally, a concluding section is given, which covers the challenges and scope for DNA assembled nanostructures as well as for the DNA assemblies-related SERS detections.
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