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Issue 34, 2011
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Unique physical–chemical, apatite-forming properties and human marrow mesenchymal stem cells (HMSCs) response of sol–gel bioactive glass microspheres

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Abstract

Bioactive glasses (BGs) are thought to be promising materials for bone tissue repair and regeneration because of their osteoconductive, osteoproductive and osteoinductive properties. Comparing with melting bioglass, sol–gel bioactive glasses (SGBGs) have been developed for bone tissue regeneration as they have the unique micro-nanoscale structure and high bioactivity in vitro. In this paper, we fabricated bioactive glass microspheres (BGMs) by a sol–gel-polymer template technology, and firstly studied the effects of morphology on their properties (physical–chemical, apatite-forming and biological properties) in detail. The surface morphology and structure, degradation, apatite-forming bioactivity and biocompatibility of BGMs were evaluated. The results revealed that the BGMs have a uniformly spherical morphology (2–6 μm in diameter) and improved amorphous structure. Comparing with irregular bioactive glass (IBG), BGMs showed slow and stable silicon release kinetics and pH stability in simulated body fluid (SBF). More uniform and needle flake-like apatite was formed on the surfaces of the BGMs. The attachment and proliferation of human marrow mesenchymal stem cells (HMSCs) cultured on the surfaces of BGMs in a short time were significantly higher than on IBG. HMSCs’ osteogenic differentiation was enhanced significantly by the BGMs, as implied by ALP activity, without adding any inducing factor, compared with IBG. Thus, BGMs possess excellent physical-co-chemical and biological properties, exhibiting their potential applications in bone tissue regeneration and drug release systems.

Graphical abstract: Unique physical–chemical, apatite-forming properties and human marrow mesenchymal stem cells (HMSCs) response of sol–gel bioactive glass microspheres

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Article information


Submitted
12 Apr 2011
Accepted
13 Jun 2011
First published
27 Jul 2011

J. Mater. Chem., 2011,21, 12725-12734
Article type
Paper

Unique physical–chemical, apatite-forming properties and human marrow mesenchymal stem cells (HMSCs) response of sol–gel bioactive glass microspheres

B. Lei, X. Chen, X. Han and Z. Li, J. Mater. Chem., 2011, 21, 12725
DOI: 10.1039/C1JM11547B

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