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Issue 29, 2010
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Hyperthermia controlled rapid drug release from thermosensitive magnetic microgels

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Abstract

Poly-N-isopropylacrylamide (PNIPAM), a biocompatible and thermosensitive polymer, exhibits reversible volume phase transition from a hydrophilic coil to hydrophobic globule at the lower critical solution temperature (LCST) of 305 K in an aqueous solution. To produce this conformational change solely by magnetic heating we incorporated magnetite nanoparticles (∼12 nm diameter) in the polymer. These PNIPAM/magnetite nanoparticle composites showed substantial heating when exposed to an alternating magnetic field. We report the non-invasive in vitro controlled release of anti-cancer drug mitoxantrone, which was loaded into the composite, driven solely by the heating induced by the external magnetic field. We found that the temperature of the composite reached 323 K in 4 min by magnetic heating, releasing 4% of the drug in this time, at an average effective release rate of 0.010 mg min−1 (corresponding to 1% per minute). We also present results on thermodynamic and magnetic anomalies near the LCST of the PNIPAM–Fe3O4 composite.

Graphical abstract: Hyperthermia controlled rapid drug release from thermosensitive magnetic microgels

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Publication details

The article was received on 26 Mar 2010, accepted on 23 May 2010 and first published on 21 Jun 2010


Article type: Paper
DOI: 10.1039/C0JM00844C
J. Mater. Chem., 2010,20, 6158-6163

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    Hyperthermia controlled rapid drug release from thermosensitive magnetic microgels

    R. Regmi, S. R. Bhattarai, C. Sudakar, A. S. Wani, R. Cunningham, P. P. Vaishnava, R. Naik, D. Oupicky and G. Lawes, J. Mater. Chem., 2010, 20, 6158
    DOI: 10.1039/C0JM00844C

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