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Issue 32, 2009
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Monoclonal antibody-functionalized mesoporous silicananoparticles (MSN) for selective targeting breast cancer cells

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Abstract

In this work, we conjugate anti-HER2/neu mAb (monoclonal antibody) to green fluorescent dye loaded mesoporous silica nanoparticles (Her-Dye@MSN) through a polyethylene glycol (MW = 5000) spacer. We examine their targeting properties toward HER2/neu over-expressing breast cancer cells and their internalization into the cells. Her-Dye@MSN nanoparticles exhibit a high targeting efficiency and the specific targeting capability is strongly affected by the mAb density on the Her-Dye@MSN. The time-course of competitive experiments with free antibody indicates that Her-Dye@MSN serves as a multivalent ligand. Moreover, Her-Dye@MSNs are internalized into cells through a receptor-mediated endocytosis and may escape from endosome to cytosol. The results reported here further support the potential of MSNs as a multifunctional smart nanocarriers for cell imaging and drug delivery.

Graphical abstract: Monoclonal antibody-functionalized mesoporous silica nanoparticles (MSN) for selective targeting breast cancer cells

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Supplementary files

Article information


Submitted
13 Mar 2009
Accepted
14 May 2009
First published
24 Jun 2009

J. Mater. Chem., 2009,19, 5737-5743
Article type
Paper

Monoclonal antibody-functionalized mesoporous silica nanoparticles (MSN) for selective targeting breast cancer cells

C. Tsai, C. Chen, Y. Hung, F. Chang and C. Mou, J. Mater. Chem., 2009, 19, 5737
DOI: 10.1039/B905158A

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