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Issue 32, 2009
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Tumor-targeting, superparamagnetic polymeric vesicles as highly efficient MRI contrast probes

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Abstract

Tumor-targeting polymeric vesicles were prepared using a mixture of two amphiphilic block copolymers, namely, folate-poly(ethylene glycol)-poly(D,L-lactide) (folate-PEG-PDLLA) and NH2-PEG-PDLLA. The copolymers were synthesized through sequential anionic polymerization in a well-controlled manner. Hydrophilic superparamagnetic iron oxide nanoparticles (SPIONs) were encapsulated in the aqueous core of the polymeric vesicles. Similar to the hydrophilic SPIONs, the SPION-loaded polymeric vesicles exhibited the superparamagnetic property. Moreover, the SPION-loaded polymeric vesicles demonstrated a higher r2/r1 value than a commercially available T2 agent, Resovist®, which can be attributed to the high SPION loading level and the SPION clustering effect in the aqueous core of the vesicles. Thus, tumor-targeting, SPION-loaded polymer vesicles can serve as highly efficient T2 contrast probes for cancer diagnosis and treatment.

Graphical abstract: Tumor-targeting, superparamagnetic polymeric vesicles as highly efficient MRI contrast probes

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Publication details

The article was received on 24 Feb 2009, accepted on 13 May 2009 and first published on 18 Jun 2009


Article type: Paper
DOI: 10.1039/B903845K
Citation: J. Mater. Chem., 2009,19, 5812-5817

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    Tumor-targeting, superparamagnetic polymeric vesicles as highly efficient MRI contrast probes

    X. Yang, S. Pilla, J. J. Grailer, D. A. Steeber, S. Gong, Y. Chen and G. Chen, J. Mater. Chem., 2009, 19, 5812
    DOI: 10.1039/B903845K

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